Position Overview: The Visiting Scholar will conduct independent research under the guidance of a scientific mentor in the areas of ovarian and endometrial cancer biology, with a primary focus on extracellular vesicle (EV)mediated mechanisms of tumorigenesis. This research aims to elucidate how EV-associated proteins contribute to cancer initiation and progression, providing critical insights for the development of novel preventive strategies, biomarkers, and targeted therapies. Growing evidence indicates that secretory epithelial cells of the distal fallopian tube (FTSECs) serve as the cell of origin for the majority of high-grade serous ovarian cancers (HGSOC). In parallel, members of the transmembrane (TMEM) protein family have emerged as oncogenic drivers in multiple cancers. This project will investigate whether TMEM205 promotes FTSEC and HGSOC cell proliferation by enhancing exosome secretion and altering exosomal protein cargo, and whether TMEM205 contributes to HGSOC progression through downregulation of PIAS3. Additionally, this research seeks to identify exosomal protein signatures unique to ovarian and endometrial cancers, with the potential to serve as clinically actionable biomarkers. The work offers strong bench-to-bedside translational relevance, providing the Visiting Scholar with opportunities to engage in clinical and translational research, particularly in ovarian and endometrial cancer.

Candidate Qualifications: We are seeking highly motivated and ambitious candidates with a PhD or MD in Biomedical Sciences, OB/GYN, or a related discipline, and demonstrated experience in gynecologic oncology and molecular biology.

The ideal candidate will have experience in: Mammalian tissue culture, Exosome/EV isolation and characterization, Transcriptional and post-transcriptional regulatory mechanisms, In vivo mouse models, particularly obesity-associated endometrial cancer models. Preference will be given to applicants with expertise in: EV biology and EV-mediated signaling and Early-stage HGSOC and endometrial cancer development

Experience Requirements

Doctoral degree (PhD or MD) in Biomedical Sciences, OB/GYN, or a related field, 12 years of research experience in cancer biology or a closely related area Demonstrated ability to conduct independent, productive research, as evidenced by: Peer-reviewed publications, Conference presentations. Contributions to novel methods, experimental designs, or translational applications relevant to ongoing research programs

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