Postdoctoral fellows will conduct research in the areas of Cancer Epigenomics and Single-Cell Technology development and application to advance cancer research. The Xu Lab investigates heterogeneous transcriptional regulation in cancer through three integrated directions: (1) developing cost-effective single-cell multi-modal technologies to track regulatory evolution across tumor progression; (2) defining epigenetic mechanisms that drive diverse cancer and immune cell behaviors and therapeutic responses, using our innovative approaches such as Paired-TF to link regulatory programs with transcriptional outcomes; and (3) dissecting transcriptional silencer regulation in oncogenesis through large-scale perturbation and single-cell profiling to uncover novel therapeutic targets.

We offer exceptional opportunities for postdocs to take strong leadership and ownership of projects, receive close mentorship, and help shape innovative research directions. Postdoctoral researchers will lead research projects, with specialization in either wet-lab experimentation on multi omics or dry-lab bioinformatic and computational analysis, present their work at international conferences, prepare research manuscripts, and participate in grant applications when appropriate.

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