Department: COP Drug Discovery and Biomedical Sciences
Advertised Salary Range: Salary commensurate with qualifications
Advertised Job Summary:
The Department of Drug Discovery and Biomedical Sciences at the College of Pharmacy, University of South Carolina, is opening a position of Research Associate in Dr. Jun Zhu's laboratory. The candidates for this position will work on ongoing R01 project funded by the National Institute of Health (NIH) to elucidate the molecular mechanisms underlying HIV-1 regulatory protein, transactivator of transcription (Tat) protein-mediated dysregulation of dopaminergic neurotransmission through the monoamine transporters and its associated cognitive deficits in concurrent cocaine or methamphetamine abusers. The duties are to characterize the in vitro pharmacological profile of the monoamine transporters as well as cognitive function and rewarding effects of cocaine and methamphetamine using HIV-1 Tat transgenic mice. Our multidisciplinary approaches include studies using cell culture (cells expressing human dopamine transporter, human norepinephrine transporter, and their mutants), radioligand uptake/binding, Co-IP and GST pull-down assays, cell surface biotinylation, transporter-mediated uptake and release, transgenic HIV-1 Tat transgenic mouse model, single residue on dopamine transporter knock in mouse model and behavioral testing.
Advertised Minimum Qualifications :
Master's degree in a biomedical sciences-related field (e.g., genetics, neuroscience, neuropharmacology, materials science, chemistry or similar) by the beginning date of employment.
The University of South Carolina System is comprised of the state’s flagship university in Columbia (founded in 1801 and currently one of the top 50 “Best Colleges” according to U.S. News and World Report), three regional comprehensive universities (USC Aiken, USC Beaufort and USC Upstate), and Palmetto College consisting of four two-year campuses (USC Lancaster, USC Salkehatchie, USC Sumter, USC Union and Fort Jackson/Extended University). Together, the USC System institutions offer more than 450 degree programs on campus and online and are uniquely positioned to meet the state’s educational, cultural, health and research needs. The System employs nearly 14,000 people who work daily to improve the lives of students, fellow South Carolinians and the world. Our diverse engaged faculty and staff enjoy a dynamic and intellectually stimulating work environment.