Rutgers, The State University of New Jersey is seeking a Postdoctoral Associate for the Center for Advanced Biotechnology and Medicine (CABM) within Rutgers Biomedical and Health Sciences (RBHS).

The primary purpose of the Postdoctoral Associate is to define cell cycle phase-specific control of cellular metabolism to identify new metabolic vulnerabilities in cancer. Each phase of the cell cycle has specific biosynthetic requirements that are necessary for successful progression, indicating that phase-specific control of cellular metabolism is essential. However, our current knowledge of cell growth and proliferation lacks sufficient understanding of how cellular metabolism is differentially regulated throughout the cell cycle. This is fundamental to unraveling the basic biology of cell growth and proliferation, and has clear implications for pathological conditions involving dysregulation of the cell cycle and metabolism. Metabolic changes that only occur in specific phases would be difficult to detect in traditional studies on asynchronously growing cell populations, thus many key aspects of proliferative metabolism remain to be discovered. The lab is providing critical new understanding of how the cell cycle controls cellular metabolism by studying metabolic regulation in individual cell cycle phases.

Metabolic reprogramming is a ubiquitous hallmark of cancer cells, induced by mutations that uncouple growth-promoting signaling and metabolic outputs from their normal regulatory inputs. Although this provides a growth advantage, locking pathways in the

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