To perform foundational and translational research on mechanisms of neurodevelopmental and -degenerative disorders caused by mutation is signaling molecules, in particular protein phosphatase 2A (PP2A) and protein kinase A (PKA). The Strack lab has postdoctoral projects in the following areas: (1) understanding disease mechanisms in Houge-Janssens Syndrome 1 (caused by de novo mutations in the protein phosphatase 2A (PP2A) regulatory subunit PPP2R5D) and Marbach-Schaaf Neurodevelopmental Syndrome (caused by de novo mutations in the protein kinase A (PKA) regulatory subunit PRKAR1B); (2) understanding cognitive impairment is cerebellar disorders (Ataxia of Charlevoix Saguenay); (3) development of phosphodiesterase inhibitors for the treatment of neurodevelopme