The UCSF Hair Analytical Laboratory (HAL) analyzes antiretroviral concentrations in hair (but may include other biological specimens such as urine, dried blood spot (DBS), plasma, serum, blood, nail, etc.) in the context of HIV and TB prevention and treatment studies using assays that are developed and validated according to the Federal Drug Administration's (FDA's) guidelines for bioanalytical methods and the National Institute of Health's (NIH's) Division of AIDS' (DAIDS) Clinical Pharmacology Quality Assurance Program (CPQA). This HAL Staff Research Associate I (SRA I) position is responsible for overseeing and maintaining high quality regulatory functions in the laboratory.
The HAL Staff Research Associate I position will assist senior analysts to determine drug concentrations in samples utilizing high performance liquid chromatographic (HPLC)-tandem mass spectrometric (LC-MS/MS) validated bioanalytical methods.
The purpose of this position is to quantitate drug concentrations for anti-human immunodeficiency virus (HIV) and anti-tuberculosis (TB) medications, primarily in human hair, dried blood spot (DBS), and urine samples (but may include other biological specimens, such as blood, plasma, serum, nail, etc.), utilizing high performance liquid chromatography (HPLC)-tandem mass spectrometry (LC-MS/MS) analytical methods for pharmacokinetic, compliance, and efficacy studies. Laboratory duties include, but not limited to, logging in samples via a laboratory data management system (LDMS); sample preparation; operating and calibrating analytical instruments; using and calibrating micropipettes; thorough documentation in lab books, log books, and paperwork; and the actual analysis (and subsequent interpretation) of data. The successful candidate will also assist in the validation of LC/MS/MS methods for antiretroviral and anti-TB drug analysis in hair, but may also include other biological specimens, in compliance with the (FDA's Good Laboratory Practice (GLP) and NIH's Division of AIDS' (DAIDS) Clinical Pharmacology Quality Assurance (CPQA) regulatory guidelines.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.