The Research Associate will work on NCI-funded therapeutic development research projects in Professor Wassana Yantasees Nanomedicine Laboratory. This position focuses on applied and preclinical research into drug candidates for treating cancers and infectious diseases (e.g., COVID-19). Our current focus is on nanoparticle-based siRNA therapeutics, vaccine, and novel cancer immunotherapy. Duties of the position include:
Lead innovative projects that expand the scope and capabilities of the technology.
Plan and conduct day-to-day experiments (e.g., molecular assays, cell culture, mouse cancer models, mouse handling/experiments, material synthesis and characterization), literature review, and trouble shooting.
Contribute to grant proposals and manuscripts.
Plan and execute toxicology studies and bioanalytics essential for IND applications of drug candidates.
Supervise Research Assistants.
Masters Degree with major courses in relevant fields and 3 years of relevant experience, or Bachelors Degree with major courses in field of research and 5 years of relevant experience
Expertise in cell culture and molecular biology techniques (e.g. Western blot, ELISA, PCR, flow cytometry)
Strong communication and interpersonal skills
Detail-oriented, strong record keeping skills
Responsible and willing to work flexible hours
Able to work as part of a team and like to take on new initiatives and challenges
PhD in molecular biology, cancer biology, immunology, or other related disciplines and 3 years of relevant experience
Experience in molecular biology (e.g., RPPA, RNASeq, CHIP-Seq, multi-color flow cytometry, multiplex assays, protein (cytokine, antibody, antigen) production in organism and purification)
Experience with immunological assays (e.g., ELISA, ELISPOT, T cell stimulation)
Experience working with mouse tumor models (e.g., xenograft, syngeneic, GEMMS, PDX, UV/chemical-induced)
Experience with in vitro and in vivo reporter assays (e.g., luminescence, fluorescence)
Experience with gene-editing tools (e.g., CRISPR, viral vectors, electroporation)
Knowledge of drug mechanism and cancer biological pathways
Knowledge of the drug development pathway and FDA regulatory hurdles
Nanotechnology development for delivery of therapeutics (e.g., antibody, siRNA, mRNA, pDNA) and diagnostics (probes/sensors)
Apply here online. Please be sure to upload a cover letter and resume or CV.
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