Staff Research Associate II, UCSF Hair Analytical Laboratory (HAL)
University of California, San Francisco
Location: San Francisco, California
Internal Number: 61786BR
The UCSF Hair Analytical Laboratory (HAL) analyzes antiretroviral concentrations in hair (but may include other biological specimens such as urine, dried blood spot (DBS), plasma, serum, blood, nail, etc.) in the context of HIV and TB prevention and treatment studies using assays that are developed and validated according to the Federal Drug Administration (FDA's) guidelines for bioanalytical methods and the National Institute of Health's (NIH's) Division of AIDS' (DAIDS) Clinical Pharmacology Quality Assurance Program (CPQA). The Staff Research Associate II (SRA II) position is responsible for overseeing and maintaining high quality regulatory functions in the laboratory.
This HAL SRA II will assist senior analysts and train and mentor junior analysts to determine drug concentrations in samples utilizing high performance liquid chromatographic (HPLC)-tandem mass spectrometric (LC-MS/MS) validated bioanalytical methods.
The purpose of this position is to design, develop, and execute a variety of analytical methods to quantitate antiretroviral drugs using liquid chromatography-tandem mass spectrometry (LC-MS/MS), primarily in hair samples (but may include other biological specimens, such as urine, dried blood spot (DBS), plasma, serum, blood, nail, etc.), for pharmacokinetic, compliance, and efficacy studies. Techniques may include, but not limited to, protein precipitation, liquid-liquid extraction (LLE), and solid phase extraction (SPE).
The successful candidate will have some knowledge and engage in analytical LC-MS/MS method development, validation, and the assaying of clinical samples in compliance with FDA's Good Laboratory Practice (GLP) and NIH's DAIDS CPQA regulatory guidelines. In addition, the candidate will also be required to prepare Standard Operating Procedures (SOPs) and Analytical Validation Reports (AVR) for submission to CPQA; respond to inquiries from CPQA; train and mentor new staff members after successfully completing and understanding internal laboratory SOPs; operate and calibrate analytical instruments; use and calibrate micropipettes; prepare, analyze, run, and interpret data; and thoroughly document in lab books, log books, and paperwork.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.