A postdoctoral researcher position in Computational Single-Cell Cancer Genomics is available in the laboratory of Dr. Allegra Petti at Washington University School of Medicine. We use computational approaches to analyze, integrate, and interpret genomic data -- with an emphasis on single-cell RNA-sequencing data -- to better understand heterogeneity and gene regulatory networks in human cancer. We participate in long-term, data-rich collaborations with established labs at Wash. U., in which quantitative analysis is closely integrated with clinical studies and molecular biology. The postdoctoral researcher will be involved in projects that use cutting-edge techniques to address topics such as the interplay of genetic, transcriptional, spatial, and immunological heterogeneity in brain tumors (e.g. glioblastoma). Opportunities to initiate and lead projects, develop new analytic methods, publish, participate in ongoing group projects, and be co-mentored by faculty collaborators are plentiful.
Primary Duties & Responsibilities
Implement and develop quantitative methods to analyze, interpret, and visualize single-cell RNA-sequencing data and spatial transcriptomic data.
Analyze WGS and exome data using pre-existing pipelines on a local linux cluster and in the cloud.
Integrate genetic and epigenetic information about tumor samples, including mutation, gene expression, and methylation data.
Develop and perform integrated pathway and gene network analyses to improve interpretability of genomic data.
Evaluate and design experimental plans for sequencing-based projects studying the genetic basis of cancer.
Communicate with collaborators, read the literature, learn about new technologies and methodologies, and write scientific publications.
Doctoral degree in computational biology, bioinformatics, computer science, statistics, biology, or a related field.
Solid background in both programming and biology, and some background in machine learning and/or statistics.
Comfortable working on a UNIX/Linux operating system, program in Perl and/or Python, and have experience with statistical analysis packages (R, Bioconductor) and bioinformatics tools.
Previous experience in cancer genomics would be an advantage.
Motivated, adept at critical thinking, collaborative, and eager to acquire new knowledge and skills on a regular basis.
Ability to analyze and interpret results, communicate with others, and produce scientific publications.
Ph.D., M.D. or an equivalent terminal or doctoral degree.
Base pay commensurate with experience.
Applicant Special Instructions
Interested candidates should submit their curriculum vitae, statement of research interests, and contact information for three references via e-mail to Dr. Allegra Petti (firstname.lastname@example.org).
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individualâ™s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.