A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
The Spindler lab in the Department of Microbiology and Immunology at the University of Michigan Medical School is a basic science lab doing molecular virology and pathogenesis research. We are actively investigating virus-host interactions using virology, immunology, molecular and cell biology approaches, on a tractable model system, mouse adenovirus type 1 infection of mice. We are recruiting a highly motivated individual for a full-time lab research position with substantial research responsibilities. The position offers opportunity for growth in leadership and research skills.
The successful applicant will be able to consult the literature or other scientists to determine the course of their own experiments with input from the PI. They will participate actively in the design of research goals, approaches, and alternative approaches. They will prepare data for presentation in manuscripts and grants, particularly for collaborative projects. They will give talks about their work locally and at international meetings. They will balance this research activity with functional lab supervision responsibilities, including training new lab personnel in lab protocols, after being trained by PI and current lab members. The successful candidate should be able to think carefully about the experiments of others and suggest modification to their experimental design, controls, and alternative explanations of the data. They will oversee/perform maintenance of cell lines and mouse colony, ordering, maintenance of lab equipment, and compliance with safety and health requirements.
Contributions to our research projects will result in co-authorship on publications whenever appropriate. Attendance at research seminars is highly encouraged.
50%: Conduct independent research in pathogenesis of mouse adenovirus and other viruses. Consult primary literature, design and execute experiments, evaluate results. Coordinate collaborations with other laboratories. Prepare data tables and figures for sharing in the collaborative projects.
30%: Maintain breeding colonies of 4 mouse lines, including husbandry and record-keeping; infect, monitor, and necropsy mice. Train research technicians, undergraduates, and postdocs in laboratory procedures, including cell culture, primary cell preparation, mouse infections and analysis by flow cytometer; virus preparation and plaque assay, RNA, DNA and protein preparations and analysis. Coordinate lab safety training for individuals. Ensure that documentation of lab inventories and protocols, safety records, hazardous waste, and radioactivity use complies with university and federal regulations. Ensure that work of lab personnel is appropriately conducted and documented.
10%: Prepare data for oral and written presentations. Present research findings at meetings. Draft primary research articles and review articles. Participate in preparation of grant proposals. Evaluate research design, hypotheses, data interpretation, and presentation for grant applications. Recommend alternative approaches to research design.
10%: Oversee/manage 1) ordering of lab supplies, 2) maintenance of lab equipment, 3) disposal of hazardous and radioactive waste, 4) hiring and training of laboratory assistant, 5) effective maintenance of cell culture lines and supplies.
B.A./B.S. plus 4 years of lab research experience.
Fundamental knowledge of/experience with mouse breeding, genotyping, infection, necropsy; sterile technique, cell culture, including primary cell preparation and maintenance; virus propagation and assays; molecular techniques including cloning, DNA, RNA, and protein analysis, including immunoblotting; immunological techniques including flow cytometry, cytokine analysis, and fluorescence microscopy; CRISPR/Cas9 mutagenesis of cell lines and mice; excellent interpersonal skills; strong writing and communication skills. Experience with regulatory compliance and data documentation.
Strong interest in developing research and leadership skills in this list through training by PI and lab personnel.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 197028
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