Regulatory interactions of ETS transcription factors.
Our goal is to determine the mechanisms of cross-talk between the epithelial-selective ETS-family transcription factors EHF and ELF5. These factors are encoded by neighboring genes located at the cystic fibrosis (CF) modifier region on chr11p13, which is associated with CF lung disease severity. EHF and ELF5 are candidate targets of the disease-associated SNPs within the non-coding regions of the modifier region. Both factors have pivotal roles in maintaining epithelial integrity and regulate multiple processes relevant to lung disease (Swahn et al., J. Cell. Mol. Med. 2019 23:7726-7740; Fossum et al., 2017 J. Biol. Chem. 292:10938-10949).
Successful applicants will have a strong record of accomplishment as shown by publications as a graduate student and/or postdoc, be highly motivated, and have a passion for elucidating disease mechanisms by functional genomics approaches.
Expertise in one or more of the following areas is required: transcription factor biology/biochemistry; post-translational modifications; cell biology; genomics technologies including ATAC-seq, ChIP-seq, cut&run, RNA-seq and the use of relevant bioinformatic pipelines.
Familiarity with general techniques of molecular biology and mammalian cell biology is essential. We are part of a vibrant and interactive research community at Case Western Reserve University and occupy excellent, modern laboratory space.
Please send an electronic letter of application, quoting the reference CWRU/AH2/2021, Curriculum Vitae and contact information of 3 referees to: firstname.lastname@example.org. Hiring is contingent upon eligibility to work in the United States.
DIVERSITY STATEMENT: In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
REASONABLE ACCOMMODATIONS: Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
Additional Salary Information: Salary based upon years of experience.
Internal Number: CWRU/AH2/2021
About Case Western Reserve University
Case Western Reserve University (CWRU): CWRU, a private research-intensive university in Cleveland, Ohio, was created in 1967 by the federation of the Case Institute of Technology (founded in 1881) and Western Reserve University (founded in 1826). Its mission is to improve people’s lives through research and education. CWRU has eight comprehensive schools: Engineering; Arts and Sciences; Applied Social Sciences; Dental Medicine; Law; Medicine; Nursing; and Management. The current student population is >11,000 (49% male and 51% female) consisting of ~5,150 undergraduate, ~2,600 graduate students and ~3,900 professional students. The excess of graduate and professional students is testament to the school’s dedication to advanced training and research. International students represent 19% of the total student population. Approximately 11% self-identify as African American, Native American, Hawaiian, or Hispanic, or mixed-race/ethnicity, and 15% are of Asian descent
School of Medicine (SOM): The School of Medicine (SOM) has a long, rich history as one of the top medical schools and research-intensive institutions in the country. Since its founding in 1843, the SOM has been ...a leader in progressive medical education initiatives and a national leader in biomedical research. Students learn in an environment that fosters scientific inquiry and excitement. A new, state-of-the-art education building opened in 2019 and houses a substantial portion of the educational activities of the Frances Payne Bolton School of Nursing, the SOM (first two years), the School of Dental Medicine and the Jack, Joseph and Morton Mandel School of Applied Social Sciences. Co-housing these educational activities highlights CWRU’s and SOM’s commitment to innovative curriculum, advanced technologies, and integration across fields.
In 1956, CWRU instituted the first MD/PhD dual degree program (MSTP) in the US. In addition to innovative education, the SOM is a national research powerhouse, garnering nearly $280M in National Institute of Health (NIH) research funding in FY18 (combining SOM, UHHS, and CCF funding), which would rank the SOM 18th among 147 US medical schools. With 13 basic science departments and 23 clinical departments, over 30 centers and institutes, and affiliations with some of the best hospitals in the country, the SOM offers graduate students the opportunity to pursue basic and translational research in great depth. In addition to the centers and institutes directly associated with the department, prominent facilities include the Centers for AIDS Research, Global Health and Human Disease, Proteomics and Bioinformatics, Stem Cell and Regenerative Medicine, Mouse Metabolic Phenotyping, and the Cleveland Center for Membrane and Structural Biology. CWRU is also home to the Case Comprehensive Cancer Center (CCCC), now in its 28th year of continuous National Cancer Institute (NCI) funding. The CCCC represents a unique collaboration for cancer research and clinical trials among CWRU, the Cleveland Clinic (CCF) and University Hospitals Health System (UHHS). The center has nearly 350 scientists and physicians as members, and is one of just 41 nationwide to hold the NCI's designation as a comprehensive cancer center.
Department of Genetics and Genome Sciences - Mission and Vision: Our Departmental Mission is to pursue cutting-edge research, provide state-of-the-art clinical care, and to train the next generation of scientists, clinicians and educators in all aspects of contemporary genetics and genomics.
As the Department is a bridge department between the SOM and UHHS, consisting of both basic and clinical genetics/genomics, we are committed to the understanding of basic genetic and genomic principles, and the translation of human genetic discoveries obtained from basic science inquiry into clinical practice. We strive to play a leadership role to bring to fruition the era of "precision medicine" in the SOM, the region and throughout the world. We house a number of core facilities used throughout the SOM, campus and affiliated hospitals. We provide educational opportunities and training for high school, undergraduate and graduate students, as well as postdoctoral research and clinical training.
Located in the heart of the culturally vibrant University Circle—home to the Cleveland Orchestra, the Cleveland Museum of Art, the Museum of Contemporary Art and much more—there's always something to do. Plus, we're just a short drive (or bike, bus or train ride) from downtown Cleveland, home to the largest performing arts center outside Broadway, some of the top restaurants in Ohio and three professional sports teams. We promise, there's plenty to do.
Equal Employment Opportunity (EEO) Statement
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216.368.3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.