Assistant Project Scientist University of California Los Angeles
Requisition Number: JPF06201
Applications are sought for a full-time Assistant Project Scientist position. The successful candidate will work as part of an interdisciplinary research team in the laboratory of Dr. Kathrin Plath's Lab in the UCLA Department of Biological Chemistry. The focus of the Plath Lab is on understanding the gene regulatory mechanisms underlying cellular plasticity and differentiation will open the door to manipulate cell identity and gene expression states and to understand disease processes. To uncover such mechanisms, the studies in the lab are informed by two key processes: the reprogramming of somatic cells to the pluripotent state and the regulation of nuclear compartments and gene expression by long non-coding RNAs (lncRNAs).
This position is intended for collaborative research working on single cell RNA and ATAC sequencing technologies and lineage tracing methods to investigate mechanisms underlying cell fate change, with a focus on being able to accomplish both experimental procedures and also develop sophisticated computational analyses. The Plath lab has described many detailed molecular mechanisms that occur during conversion of somatic cells towards induced pluripotent stem cells and is looking to deeply understand the stochastic mechanisms that induce the pluripotent state in somatic cells. In addition, the person hired into this position will lead collaborations with other labs on applying single cell genomics approaches and the computational analysis of the data.
A successful candidate(s) will have the following qualifications:
PhD in a Biological or Computational Discipline
Ability to work in a collaborative interdisciplinary environment
Expertise in computational analysis of single cell genomics data sets
Experience working with and analyzing chromatin assays such as ATAC-seq, RRBS, ChIP-Seq etc.
Experience in establishing new methods and approaches
First author publication preferred
Job duties and responsibilities
Participate in the planning of grant goals and gathering pilot data for such proposals
Responsible for writing grant proposals for submission to federal and private funding agencies
Responsible for writing research papers for publication
Responsible for progress reporting to granting agencies
Seek funding to establish own independence
Responsible for supervising lab members including undergraduate students, graduate students, postdocs, lab helpers and high school students
Responsible for maintenance of lab instruments and training new users in their operation (tissue culture equipment, microfluidics setups, sequencing preparation machinery such as sonicators)
Conduct research into cell identity and cell fate change mechanisms, using single cell technologies, lineage tracing, and inventive analysis to describe molecular mechanisms that occur during conversion of somatic cells towards induced pluripotent stem cells and in the reverse process of differentiation
Manage collaborative projects related to the study of developmental and
disease processes using single cell approaches
The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. UC Nondiscrimination & Affirmative Action Policy
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The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction
UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.