A postdoctoral position is available to study a newly-discovered pathway, which links transcription and RNAPII CTD kinases with mRNA 5-cap remodeling by mTORC1 for facilitated translation in the cytoplasm, is critical for ovarian, breast and prostate cancer metastases. The project will explore how the CDK12 kinase affects signaling under NRF2/oxidative stress conditions, as well as during human embryonic stem cell renewal and differentiation. A novel regulator of CDK12, which is essential for mitochondrial oxidative phosphorylation will also be characterized and studied for insights to inhibit this step in cancer.Prior experience with ChIP-seq,RNA-seq, imaging, and molecular and biochemical/proteomics techniques would be relevant.
PhD degree in Biological Sciences.
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