The OHSU Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. Driven by its mission to end cancer as we know it, the institute is building upon its expertise in targeted treatments to advance the early detection of cancer when the disease is most treatable.
The OHSU Knight Cancer Institute is the benefactor of $1 billion in philanthropic to overhaul early detection of lethal cancers and to recruit some of the worlds leading researchers. The Cancer Early Detection and Advanced Research (CEDAR) center within the Knight Cancer Institute as a result offers a unique opportunity for outstanding, driven and creative postdoctoral candidates to perform cutting edge and high-risk research ranging from understanding basic cancer biology to developing novel technologies to aid detection. To expedite the process of discovery, CEDAR offers generous internal funding mechanisms open to researchers at all stages of their career.
Every Knight Cancer employee is expected to embody our guiding principles:
We act BOLDLYBreakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
We SUPPORT each otherRespect leads to trust, which leads to excellence
We work as a CONNECTED team We must leverage our collective brain power to conquer cancer because no one individual can do it alone
As part of this fellowship a successful candidate will have the opportunity to work with researchers in the CEDAR program, led by Dr. Sadik Esener, and researchers in the Precision Oncology Program, led by Dr. Gordon Mills. CEDAR is focused on detecting and treating lethal cancers at the earliest stage and the Precision Oncology Program is focused on obtaining a deep understanding of patient tumors to identify effective therapy for cancer patients. Candidates will work closely with Prof. Gordon Mills, Dr. Hisham Mohammed and other CEDAR researchers to develop key questions on cancer initiation or develop novel single-cell and proteomics tools relevant to early detection and precision oncology.
We are hiring 1-2 highly motivated Postdoctoral Fellows to address the following general themes:
Develop existing or novel technologies with the aim of accurately monitoring biological processes at a single-cell proteomic, transcriptomic and epigenetic level. The team has previously developed proteomics (RIME, RPPA), single-cell and multi-omic technologies (Mohammed et al, Argelaut et al). Of particular interest is integrating tumor spatial information with single-cell transcriptomics, epigenetics (methylation, chromatin accessibility) and proteomics. This position will leverage unique partnerships with industry innovators.
Investigate fundamental biological processes of cancer initiation and progression. Current interests include deciphering the role of hormone receptors (Mohammed et al, Nature 2018) and deep spatially oriented proteomic analysis of patient tumors to determine therapeutic opportunities. CEDAR researchers have unique access to longitudinal clinical samples and trials to test emerging hypotheses.
Computational biologists with an interest in driving single-cell and multi-omic projects in clinical settings are also encouraged to apply. The position may also involve developing new computational methods and deep learning tools to complement novel technologies developed in the lab.
1. Mohammed, H. et al. Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor. Cell Reports 3, 342349 (2013).
2. Mohammed, H. et al. Progesterone receptor modulates ER action in breast cancer. Nature 523, 313317 (2015).
3. Heiser, L. M., Mills, G. B. & Gray, J. W. Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers. Cancer Cell 35, 341343 (2019).
4. Clark, S. J. et al. scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells. Nature Communications 9, 390 (2018).
5. Lee, J. et al. Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies. Molecular & Cellular Proteomics 17, 12451258 (2018).
Perform experiments utilizing specialized techniques in mammalian cell culture, sequencing, gene mapping, single cell analysis and epigenetic regulation analysis with proficiency.
Use expert training received in PhD to evaluate results, and independently determine the next steps to complete project and present data. Think creatively and problem solve.
Stay on top of the literature and build skills to maximize the projects potential.
Prepare manuscripts, and present research findings as abstracts or oral presentations (travel may be required).
Attend weekly group meetings and 1:1 meetings to: 1) present data and interpretation of results; 2) troubleshoot research results and 3) suggest next steps.
PhD in relevant field such as cellular biology, computation, or engineering
Passion for science and inquiry
Ability to prioritize multiple tasks at one time
Must have excellent communication, analytical and organizational skills, both written and verbal
Ability to work independently and as part of a team while being collaborative in resolving problems
Must be proficient with computers running Windows and PC applications e.g. MS Excel, Oracle, Access, Word and PowerPoint)
Must have demonstrated excellent customer service skills both on the phone and in person
Must possess energy and drive to coordinate multiple projects simultaneously
Ability to use tact and diplomacy to maintain effective working relationships
Cancer research experience
Ability to synthesize scientific projects and communicate science to diverse audiences
Experience with cancer research
Experience with data analysis
Apply online and include your resume anda cover letter.
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or firstname.lastname@example.org.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm